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In contrast, aged animals exhibited no significant changes in macrophage cytokine levels, suggesting that Epitalons therapeutic value may lie more in correcting age-related immune deficits than in stimulating already functional systems
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Another meta-analysis (8 trials and 761 patients) similarly reported that melatonin as an adjuvant treatment for solid tumor cancers substantially improved tumor remission, 1-year survival, neurotoxicity, and fatigue and alleviated radiochemotherapy-related side effects [55]
In both studies, eGFR was assessed cross-sectionally in yearly intervals for up to 10 years and longitudinally for 5 years
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