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10.1016/j.surg.2006.07.038 84 KhederS.SisleyK.HadadS.BalasubramanianS
Off-label use for low-BMI cosmetic weight loss is not supported by the evidence, exposes the patient to real risks (including rapid muscle loss and rebound after discontinuation), and typically isn't covered by insurance
For example, variants in the FTO gene (fat mass and obesity-associated gene) are linked to increased hunger drive and a higher set-point weight
Drink fluids between meals, not with them
Today, the FDA is announcing its intent to take decisive steps to restrict GLP-1 active pharmaceutical ingredients intended for use in non-FDA-approved compounded drugs that are being mass-marketed by companies including Hims & Hers and other compounding pharmacies as similar alternatives to FDA-approved drugs
In SURMOUNT-5, 6.1% of Tirzepatide patients stopped treatment due to adverse events compared to 8.0% on Semaglutide
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