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Thus, in our reconstituted system, PDS5B and miniBRCA2-DSS1 functionally co-operate to enable the use of RPA-coated ssDNA as template for RAD51-mediated strand exchange, with the DNA binding attribute of PDS5B being indispensable in this regard

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Furthermore, activation of GLP-1R significantly inhibited the ER stress-induced nuclear translation of NF-B and reduced expression levels of inflammatory molecules in TG-induced chondrocytes

A small human pilot study conducted showed no side effects

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