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There is a theoretical case for using both in certain patients, targeting different physiological mechanisms simultaneously, though this approach is under evaluation and not yet standard of care

The two pathways converge on somatotroph GH release through independent second-messenger cascades, and the combined-receptor pharmacology in healthy-adult human preparations across the Bowers laboratory work in the 1980s and 1990s reported a larger GH excursion under combined GHRH-analog plus GHRP-class administration than under either compound singly [6]

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