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This rapid neutralization prevents ROS from tearing electrons away from healthy cellular structures, effectively putting out the biochemical fires driving chronic inflammation

How They Actually Work in Your Body Unlike restrictive diets that fight against your biology, GLP-1 medications work with your body in four key ways: They slow digestion : Food stays in your stomach longer, so you feel full sooner and for longer periods

May 6 2024;43(1):59

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TLDR: "Discontinuation of GLP-1RA treatment leads to weight regain, regardless of lifestyle interventions, and should therefore be considered a chronic therapy to prevent weight regain and associated undesirable outcomes related to obesity." Key findings: After stopping liraglutide, patients regained ~2.2 kg After stopping semaglutide/tirzepatide, patients regained ~9.7 kg Weight regain was proportional to initial weight loss Lifestyle changes alone DID NOT prevent regain Implication: GLP-1 receptor agonists are not a short-term solution

Semaglutide drives weight loss through cAMP-dependent mechanisms in GLP1R-1 expressing hindbrain neurons by Claire Gao, Isabelle C