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The chronic negative energy balance induced by semaglutide leads to sustained reductions in body weight, preferentially reducing fat mass with relative preservation of lean mass compared with nonpharmacologic weight loss alone

This can help prevent interactions and reduce the risk of hypoglycemia

But when GLP-1s are excluded, that figure drops sharply to $370 million

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Youre Not Exercising "An activity prescription is an essential part of all long-term [weight loss] plans, says Richard Siegel, MD, an endocrinologist and a codirector of the diabetes and lipid center at Tufts Medical Center in Boston