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Circulation 107(3):499511

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However, insights from cardiovascular and kidney outcome trials in individuals with T2D have shifted current guidelines toward a disease-modification approach

More recently, innovative molecules like the dual glucose-dependent insulinotropic polypeptide and the glucagon-like peptide 1 (GLP1R-GIPR) receptors agonists, such as tirzepatide, have shown even greater efficacy, with weight loss up to 18% [21]

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Staggering two agents may make a reaction easier to attribute, but it does not validate an unapproved agent or make the combination evidence-based