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In 2014, LaRocca et al
370 Notably, the NATALEE trial included 40% of patients who were excluded from the MonarchE study due to having stage II and stage III N0 disease, making it a more comprehensive clinical trial of CDK4/6 inhibitors in early breast cancer to date
Other reported mechanisms include activation of FAK-paxillin complexes (which help cells migrate and attach to surfaces during wound healing), JAK-2 signaling, and ERK1/2 pathway activity (Sikiric et al., Current Neuropharmacology, 2016
In particular, it influences cell proliferation and renewal
As a shared therapeutic target for DM and its complications, NRF2 activation holds promise as a novel therapeutic strategy
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