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The clearance (L/hr) of APAP increased from 2.02 L/hr at 1 month of age to 4.09 L/hr at 1 year of age to 14.27 L/hr at 16 years of age (based on our own analyses on the published mean values with a Spearman correlation, there is a significant correlation between age and APAP clearance, p G (rs8330) is associated with increased human liver acetaminophen glucuronidation, increased UGT1A Exon 5a/5b splice variant mRNA ratio, and decreased risk of unintentional acetaminophen-induced acute liver failure

Through this review, we were able to better find novel clinical therapeutic directions for further TBI study

(Primary completion November 2025, 68-week treatment period, 4mg/9mg/12mg dose arms

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Sample sizes were chosen on the basis of extensive experience with the assays we have performed