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The clinical trials started every participant at 0.25 mg for good reason
Most reported effects are mild, but you should understand them before you start, and they are part of why ongoing monitoring matters
You don't need a massive "megadose" once a month
A systematic review reported no associations between GLP-1RAs and serious psychiatric effects, including psychosis, major depression, or suicide
However, patients in more advanced stages or those on dialysis require more frequent evaluations, especially during dose adjustments
In this study, we show that isolated mitochondria exposed to colistin undergo rapid depolarization of the mitochondrial inner membrane, indicating that mitochondrial damage is likely to be an early event in colistin-induced kidney injury
