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Science 382 , 12261227 (2023)

The lesson: being a slow starter does not predict a poor final outcome

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For hypothesis H3, the model simulations showed that the sinusoidal export activity of hepatocytes has to be increased by about 110-fold for the midazolam model and by 12-fold for codeine to explain the observed glucuronide blood concentrations in cirrhotic mice (Figure 6E

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They concluded that these improvements were related to the acetyl L-carnitine (ALC)/ALA combinations ability to protect and repair age-induced mitochondrial DNA damage, thereby boosting mitochondrial function and improving energy turnover