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The next decade will be pivotal in translating accumulating clinical and preclinical findings into meaningful therapies that can prevent or reverse the course of DN, ultimately improving outcomes for millions of patients
The combination of a DPP-4 inhibitor with insulin is particularly attractive because it does not significantly increase the risk of hypoglycemia, as the insulin secretagogue effect is glucose-dependent
Understanding why the evidence for DSIP is weak, and being able to say so plainly, is itself a clinical skill
Patients sometimes miss eligibility thresholds by a small margin
SOD and catalase, another ROS antagonist, to some extent reduced the secretion of GAGs induced by IL-1, suggesting that ROS may be involved in the IL-1-dependent release of GAGs
DCF diacetate was added to 80 g protein aliquots, which were incubated at 37 C for 30 min
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