Tesamorelin and Ipamorelin are growth hormone secretagogues, meaning they prompt your own pituitary to release growth hormone, while MGF (Mechano Growth Factor) acts locally inside muscle tissue after exercise
At least for metformin it can be expected that current clinical trials will catch upon this
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Amylin (cag) tells your hindbrain you are full
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Journal of gastroenterology and hepatology 27 , 323330 (2012)