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Results vary, and they may not match what patients see with injectable medications

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These medications were originally developed for type 2 diabetes and are now approved for weight management

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On the one hand, by triggering the Gq/PLC signaling pathway and mitochondrial reverse electron transport-mediated ROS bursts, it induces the oligomerization and activation of the NLRP3 inflammasome, driving the maturation and secretion of pro-inflammatory cytokines such as IL-1 and IL-18, thereby significantly amplifying local intestinal inflammatory responses (Bauset et al., 2022) (Figure 1B)

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Written by: Rafael Guimares, MS & Kristen DiFilippo, PhD, RDN Glucagon-like peptide 1 receptor agonists, commonly known as GLP-1 medications, are increasingly used in the treatment of type 2 diabetes and obesity (Drucker 2018

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