It works with your physiology over time, so consistency and follow-up testing matter more than any single dose
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(B6, especially in the pyridoxine form, is one of the few B vitamins that can lead to toxicity when used in excess.) Threonine is also important to gut barrier integrity in the small intestine, and I have read some reports of it helping with minimizing reactions to gluten, although I have not studied this in great depth yet
What adverse effects are expected, and who manages them
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Patients should aim to maintain balanced nutrition despite reduced appetite, focusing on nutrient-dense foods