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Importantly, emerging evidence suggests that combination therapy with GLP-1 RAs and SGLT2is may provide synergistic benefits, producing greater reductions in body weight, glycated hemoglobin (HbA1c), and potentially liver-related endpoints compared with either therapy alone
The SURPASS-1 trial investigated the efficacy and safety of the three doses of 5, 10, or 15 mg tirzepatide in drug-nave patients with T2D who were not sufficiently controlled with a lifestyle intervention with diet and exercise versus placebo (70)
Research indicates DSIP may promote delta-wave (slow-wave) sleep, modulate cortisol and ACTH levels, and exhibit stress-protective properties [3] [4]
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When the condition is suspected or known to occur in a family, genetic testing can be helpful in identifying the specific individuals who have or carry the disorder
