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Due to various external influences such as stress, the ratio of the two can become unbalanced and the oxidised form gains the upper hand
Endpoints: NO markers, regulation of vascular flow, parameters of the gut-brain axis in rodent models
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Insert needle at recommended angle for chosen route (IM or SC)
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But animal studies extending up to 6 months show no organ toxicity or adverse histological changes (Sikiric et al., Toxicology and Applied Pharmacology, 2019)
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