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The intranasal delivery route enabling direct brain access suggests potential for bypassing blood-brain barrier limitations that restrict many therapeutic agents
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Two reasons: (1) similar half-lives (~7 days each) make a single weekly protocol pharmacokinetically practical, and (2) the GLP-1 + amylin combination engages two complementary metabolic pathways
B12 injections fit into this approach because they may help reduce one of the biggest barriers to adherence: feeling drained
Bennett RG, Duckworth WC, Hamel FG
