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Trump hosted Japanese Prime Minister Sanae Takaichi at the White House on Thursday, during which he praised Tokyo for really stepping up to the plate on Iran, unlike NATO. Although Japan has also stopped short of deploying forces to the strait, Takaichi has doubled down on her pro-Trump rhetoric, perhaps hoping that words appease the White House as much as actions do

Approval Timeline and Availability CagriSema: Ahead in the Race FDA Submission: December 18, 2025 (NDA filed) Expected FDA Decision: Q4 2026 or Q1 2027 Predicted Launch: Mid-2027 Advantage: 6-12 month head start on retatrutide REDEFINE Program Status: REDEFINE-1: Completed (obesity, 20.4% weight loss) REDEFINE-2: Completed (type 2 diabetes, 13.7% weight loss) REDEFINE-3: Ongoing (cardiovascular outcomes trial) REDEFINE-8: Ongoing (body composition study) High-dose CagriSema (2.4/7.2mg): Starting late 2026 Retatrutide: More Trials Needed FDA Submission: Expected Q4 2026 or Q1 2027 Expected FDA Decision: Late 2027 Predicted Launch: Q1-Q2 2028 TRIUMPH Program Status: TRIUMPH-4: Completed (osteoarthritis, 28.7% weight loss) TRIUMPH-1: Complete 28.3% weight loss (May 2026) TRIUMPH-2: Expected Q3Q4 2026 (obesity + type 2 diabetes) TRIUMPH-3: Expected later 2026 (obesity + cardiovascular disease) TRIUMPH-6: Weight maintenance trial (ongoing) Disadvantage: Needs more trials before submission, 6-12 month delay vs CagriSema

The benefit comes from replacing whats missing, not from extra B12 on top of normal levels

For those already pregnant or those newly pregnant we recommend consulting with your doctor

[1] Tirzepatide may cause fetal harm and should be discontinued at least 2 months before a planned pregnancy

Nature 590 , 473479 (2021)