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Transcription corepressor CtBP is an NAD(+)-regulated dehydrogenase

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In Studies 1 and 2, all patients received a standard lifestyle intervention which included instruction on a reduced-calorie diet (approximately 500 kcal/day deficit) and increased physical activity counseling (recommended minimum of 150 min/week) that began with the first dose of study medication or placebo and continued throughout the trial

Isso se torna interessante, especialmente para aqueles que tem por objetivo poupar o glicognio muscular, uma vez que a fonte de energia passa a ser a gordura, e o glicognio pode ser utilizado em outros momentos durante a prtica de exerccio