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Goldenberg RM, Cheng AYY, Fitzpatrick T, Gilbert JD, Verma S, Hopyan JJ

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PYY(336) and exendin-4 reduce food intake and activate neuronal circuits in a synergistic manner in mice

[10] [11] The mechanism by which these medications reduce appetite involves both peripheral and central pathways

Bbs5 / mice had a pancreas size similar to that in WT mice (Figure 1P), but displayed pancreatic islet hyperplasia (Figure 1Q), with a greater percentage of islet relative to pancreas area (Figure 1R), larger average islet size (Figure 1, S and T), and an increased number of insulin cells per islet (Figure 1U)

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