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Pre-medication with a bronchodilator may be recommended in such cases.

[7] Signs of an allergic reaction (such as rash, hives, or anaphylaxis) preclude further use

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Mitochondrial dysfunction leading to oxidative stress also induces FGF21 expression in preclinical disease models ( Enhanced secretory load, imbalances in redox homeostasis, or perturbations in protein homeostasis triggered by lysosomal or autophagosomal dysfunction may all cause ER stress and trigger the unfolded protein response (UPR)