Markland AD, Palsson O, Goode PS, Burgio KL, Busby-Whitehead J, Whitehead WE
L.BraunwaldE.StegP
It ferments slowly and produces significant amounts of butyrate, a short-chain fatty acid that plays a crucial role in maintaining colonic health and reducing intestinal inflammation
Evidence-based weight management recommendations prioritise: Achieving a sustainable calorie deficit through dietary modification (typically 500-600 kcal/day reduction) as recommended by NICE guideline NG246 Increasing physical activity to at least 150 minutes of moderate-intensity exercise weekly, in line with UK Chief Medical Officers' Physical Activity Guidelines Behavioural strategies including self-monitoring, goal-setting, and addressing psychological factors Consideration of NHS weight management services based on local referral criteria, typically for those with BMI 30 kg/m (or 27.5 kg/m for South Asian, Chinese, and other minority ethnic groups) with comorbidities If choosing to trial probiotic supplementation, select products that specify the bacterial strains and colony-forming units (CFUs) on the label
Microdosing strategies fall below these ranges and have not been evaluated in large randomized trials
It was found that higher prevalence of Akkermansia levels in the gut microbiota are inversely related to insulin sensitivity, fasting glucose, waist-to-hip ratio, body fat mass, and plasma triglycerides, corroborating previous evidence in mice of the effects of Akkermansia for regulating metabolism
