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FIGURE 6 Cellular Validation of the Specificity of GPX4 Activator To further evaluate the selectivity and specificity of compound 102 in a cellular context, we employed the cellular thermal shift assay (CETSA

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18 In kidney injury, extracellular vesicles and secreted lipid mediators are sufficient to synchronize ferroptotic death across spatially contiguous tubular epithelial cells, thereby contributing to a self-amplifying wave of tubular death during the transition from acute kidney injury to chronic kidney disease

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Although not in the schema, it is conceivable that RXS via CYP might be involved in the genesis of autoimmune pancreatitis, as in autoimmune hepatitis (60): this becomes plausible with the finding from studies in hepatocytes that newly synthesised CYP enters the secretory pathway to arrive at the outer surface of the plasma membrane (119)

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