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The progression: mono dual triple The clinical progression across incretin agonists illustrates the rationale, using reported trial weight-reduction figures as the anchor: Semaglutide (mono-agonist): ~15% body-weight reduction in Phase 3 trials Tirzepatide (dual agonist): ~22% body-weight reduction in Phase 3 trials Retatrutide (triple agonist): ~24% in Phase 2, and ~28% at the highest dose in the Phase 3 TRIUMPH-1 obesity readout (2026) Each generation extended the effects of the previous, with the triple agonist at the current frontier
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The second accelerator is tirzepatides performance advantage crystallizing a new efficacy standard
R., Holtug, K
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