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Within this framework: HRT supports neural bioenergetics and mitochondrial stability, helping sustain adequate energy supply GLP-1 therapies reduce systemic and central inflammatory stress, improving the environment in which neurons function Rather than acting in isolation, these therapies may operate synergistically to stabilize both energy production and stress response systems within the brain

Additional cautions apply to patients with thyroid nodules or elevated calcitonin levels, which warrant appropriate diagnostic evaluation rather than automatic exclusion from therapy

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For a practical guide on managing denials and financial fallbacks when PA doesn't go through, see When PA Is Denied: Management, Appeals & Financial Fallbacks

PubMed , International Journal of Molecular Sciences , vol