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Some of these agents have been approved for daily clinical practice

The 2024 Yang paper in Journal for ImmunoTherapy of Cancer documented NNMT in cancer-associated fibroblasts driving tumour progression (PMID 39067875)

Dihexa in low milligram amounts, though Dihexa dosing is poorly standardized given the lack of human trials

Step 4: dissolve gently Do not shake the vial