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however, it decreased ROS, MDA production, and mitochondrial damages induced by multidrug treatment, and increased GSH synthesis

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Internal changes during this phase include upregulation of collagen genes, increased growth factor production, and early accumulation of new extracellular matrix components

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In recent years, ferroptosis has emerged as a promising target for countering highly aggressive malignancies, and is an iron-dependent form of regulated cell death associated with accumulation of reactive oxygen species (ROS) and increased lipid peroxidation 7

J Biol Chem 285(11):81718184 Katsiki M, Chondrogianni N, Chinou I, Rivett AJ, Gonos ES (2007) The olive constituent oleuropein exhibits proteasome stimulatory properties in vitro and confers life span extension of human embryonic fibroblasts