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Seiwerth S, Brcic L, Vuletic LB, et al
This macrophage reprogramming is associated with SFN-mediated inhibition of the transcription factor c-Myc, which normally drives M2 polarization, and concurrent activation of the Nrf2 pathway that favors M1-associated gene expression profiles (78)
It should be emphasized that the mechanism of selenium toxicity in yeasts might be associated with the process of its reduction to elemental form
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thus, the spectrum of GSS mutations and the genotypephenotype association remain unclear
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