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Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): A randomised, open-label, parallel-group, phase 3 trial

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Simultaneously, these medications suppress glucagon secretion from pancreatic alpha cells, reducing hepatic glucose production

Intramuscular sites include the arm, thigh, and hip

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