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In breast cancer, this synergy is elaborated in Section 4.6 on chemotherapy, highlighting its impact on tumor progression (84)
This is due to the hydrophobic nature of isoleucine and alanine, which leads to a less soluble peptide that adopts an equilibrium of monomers, trimers and tetramers, whereas A 140 is mostly monomeric (Chang and Chen, 2014)
References 1 SunHSaeediPKarurangaSPinkepankMOgurtsovaKDuncanBBet al
However, unnecessary supplementation offers no added benefit if your B12 levels are already normal
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