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1 The different GLP-1 RAs vary in the number of antibodies seen in clinical trials, with exenatide (once weekly) having the greatest and dulaglutide and albiglutide having the least

53 Generally, the reported K m of PARP1 and CD38 for NAD + are lower than those of the sirtuins, suggesting that elevated activation of PARP1 or CD38 may limit endogenous SIRT activation by reducing NAD + content

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