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Animals were randomly divided into five groups (n = 6 per group): Sham, DMM, DMM + DMSO, DMM + DMSO + OSR-down (25 mg/kg), and DMM + DMSO + OSR-up (50 mg/kg)
Its less effective for hair loss caused by autoimmune conditions such as alopecia areata, scarring alopecia, or complete baldness, in which follicles are already gone
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In mice, TLC-2716 was administered orally at 15, 60 and 120 mg per kg (body weight) per day (7- to 57-fold the maximum clinical dose) to lean male and female CD-1 mice for 26 weeks
S., Li, H
The brightening on the deeper skin tones tends to go unnoticed later and require a longer period of time since the melanin activity is more prominent by nature
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