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10.3389/fcell.2020.00796 108 LiJ.HuynhL.CornwellW

PMR has been shown to lower blood pressure and heart rate, both of which can help initiate sleep and prevent mid-night awakenings

Previous studies have shown that GLP-1 signaling stimulates insulin gene expression and biosynthesis 22 , enhances glucose-stimulated insulin secretion 23 , restores glucose competence in glucose-resistant -cells 24 , and stimulates -cell mass expansion 20

The gap between the two groups continued to widen from one to six months after the procedure, suggesting the benefits may persist and even strengthen over time

Sulfur burps can be an unpleasant but often temporary side effect of GLP-1 medications

careful riskbenefit assessment is warranted Those with pre-existing gallbladder disease : Rapid weight loss can precipitate gallstone formation or worsen existing biliary conditions People with severe gastrointestinal disease, including gastroparesis : GLP-1 receptor agonists slow gastric emptying, which may worsen symptoms in those with pre-existing gastric motility disorders Older adults : Age-related changes in renal and hepatic function may affect drug metabolism and increase sensitivity to side effects