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Beyond glycemic control and weight loss, tirzepatide exerts comprehensive effects on metabolic homeostasis, including improvements in insulin sensitivity, lipid metabolism, and inflammatory status

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For example, glucose is absorbed by the intestine and enters the portal vein, where glucose sensing increases hepatic vagal signaling to the NTS 52 and subsequently to the hypothalamus 53 to decrease food intake 54,55 and regulate glycemia 56,57

However, it has been reported that the aryloxyl radicals are sometimes unstable showing a prooxidant behavior (Bors et al

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The development of gut hormone dual- and triagonists holds promise for treating obesity and T2DM with a level of effectiveness comparable to bariatric surgery