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Based on the observation that Keap1 functions as a homodimer, the heterozygous missense mutation generates three types of Keap1 dimers, i.e., wild-type homodimer, wild-type-mutant heterodimer, and mutant homodimer at a ratio of 1:2:1
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Zhang Y, Liu Y, Liu H, Tang W
Very high doses of B12 taken orally may occasionally cause mild gastrointestinal disturbance in some individuals, though this is uncommon
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