The STEP trials assessed the efficacy and safety of semaglutide 2.4 mg in individuals with overweight (BMI 27.0 kg/m with at least one weight-related comorbidity) or obesity (BMI 30.0 kg/m), both with and without T2D or prediabetes
doi:10.1016/S2213-8587(24)00163-3 Cai TT, Li HQ, Jiang LL, et al
Zheng, Y., Lai, L., Liu, W., Jiang, H
In the Zepbound trials, nausea occurred in roughly 25-29% of patients, diarrhea in about 19-23%, vomiting in about 8-13%, and constipation in about 11-17% across doses, along with abdominal pain
But the drugs high cost has prompted several commercial insurance companies to drop coverage
Before ending the discussion, its a good idea to make a plan to check in on your progress with your doctor