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They should also identify whether metabolites add information beyond simple clinical variables such as blood pressure, body mass index, diabetes, renal function, natriuretic peptides, troponin, and LV mass

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In an Escherichia coli model, LONP1 with mutations in its proteolytic domain still effectively suppressed the aggregation of unfolded proteins, confirming that its chaperone activity is independent of its proteolytic function [38]