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Hayashi Y, et al

2): Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks the insulin-producing cells of the pancreas and destroys them

2 GLP-1: a key player in metabolic homeostasis GLP-1 is a 31 aminoacid-long peptide derived from proglucagon (15), which is produced in response to both nutritional and inflammatory stimuli

These indirect mechanisms allow for central nervous system modulation without requiring substantial penetration of the blood-brain barrier, though direct human data on CNS distribution of long-acting incretin agonists remain limited