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The AUGUSTUS trial (N=4,614) showed that adding aspirin to apixaban in patients with atrial fibrillation and recent acute coronary syndrome increased bleeding events from 7.3% to 10.9% over 6 months (HR 1.89, 95% CI 1.59 to 2.24) [12]

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In some cases, you may need to give the medication more time

The panel's recommendations are non-binding but they carry significant weight with the FDA

It's the evidence that's been rigorously tested, clearly communicated, and directly relevant to how healthcare actually works outside the trial setting