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Clinical trials have demonstrated that nausea, diarrhea, vomiting, constipation, and abdominal discomfort occur frequently, particularly during dose initiation and escalation

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What a Careful Reader Should Take Away Use the CHS finding to question a simple blood-concentration model

Reviewers have repeatedly noted the need for randomized controlled trials before any therapeutic claim can be supported [12]

It remains in Phase 3 clinical development, and regulatory submissions to the MHRA and EMA have not yet been completed