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pylori ) is a gram-negative pathogen that colonizes gastric epithelial cells, and its chronic infection is the primary risk factor for the development of gastric cancer (GC)

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In contrast to other GPxs, GPx4 is the only one that reduces the hydroperoxides of lipoproteins and complex lipids, such as cholesterol, cholesterol esters, and phospholipids [108], to protect mitochondrial ATP generation from oxidative damage [109]

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This fundamental mechanism underpins its efficacy in repairing a wide array of tissues, from gut mucosa and muscle tendons to neural tissue

10.1016/j.jinorgbio.2015.09.003 J