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T., Garcia, L
Years of post-marketing data, cardiovascular outcome trials showing actual event reduction, kidney benefits, and extensive real-world experience provide a level of certainty that retatrutide simply cannot match yet
The long-term outcome phase (months 4-12) establishes final post-treatment baseline revealing maximum durable benefits maintained without ongoing GHK-Cu use
And of course, you cant make an inference based on three people, but it is what motivated me to start looking into more of the psychological effects, particularly around what we do and do not know about how GLP-1s affect dopamine and motivation-seeking behavior
doi: 10.1177/1178646920936279 46 LongoNFrigeniMPasqualiM
A 2025 study published in JMIR Formative Research found that active subscribers on Second Natures GLP-1-supported programme lost an average of 19.1% of their body weight at 12 months, with 77.7% achieving at least 10% weight loss
