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Extended Timeline Support Establish funding mechanisms that support long-term investigation, allowing researchers to follow promising leads even when they diverge from original proposals

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The peptide also delivers copper as a cofactor for lysyl oxidase and lysyl hydroxylase, enzymes essential for proper collagen cross-linking and structural integrity

Moreover, it appears that it is the membrane-bound form of the enzyme, on sites such as the luminal surface of capillary endothelial cells, which is more important for GLP-1 degradation than the circulating (soluble) enzyme (74, 75), questioning the relevance of any association between the plasma activity per se and glycaemic control, since it is unclear whether changes in soluble DPP-4 activity in the circulation accurately reflect any changes in total DPP-4 activity