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Treatment duration proves critical variable where longer courses create more durable changes - users completing 2-3 month treatments typically maintain 20-40% of peak benefits long-term, 4-6 month treatments sustain 40-60% of improvements, and 6-12+ month courses preserve 50-70% of maximum benefits potentially indefinitely
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The trial was powered to detect a 1.8 kg difference vs placebo
N Engl J Med 2003
Cysteine is the most vital precursor in the biosynthesis of glutathione
PMC 281544
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