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Moreover, exerkines such as irisin activate the Nrf2/HO-1/HMGB1 pathway (154, 155), a central regulator of the antioxidant response, while others including decorin, BDNF, adiponectin, and FGF21 may also contribute to mitigating oxidative stress (165168)

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Sinomenine improve diabetic nephropathy by inhibiting fibrosis and regulating the JAK2/STAT3/SOCS1 pathway in streptozotocin-induced diabetic rats

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