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The data were given as a threshold cycle (C T ) and fold changes in gene expression were calculated as 2 CT C T over the housekeeping gene RPII

In a comparative study the size dependency of BBB uptake and permeability was investigated for nanoparticles from 50 to 500 nm of various composition (polystryrene, protein, lipid) on a human culture BBB model in which transferrin nanocarriers with 500 nm diameter showed the most successful BBB penetration [61]

Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk