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Pregnancy and breastfeeding are periods where these therapies are generally deferred, since they are not studied in those groups, and anyone managing a serious or unstable medical condition should be evaluated and cleared before starting

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An NPR report from February 2026 explored the benefits and risks of using GLP-1 medications at a normal BMI, noting that the long-term effects of these drugs in normal-weight populations are not well studied

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therefore, there has been a sense of caution about such use

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