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How GLP-1s work for weight loss
N Engl J Med 384(11):9891002 Wilding JPHBR, Calanna S, Van Gaal LF, McGowan BM, Rosenstock J, Tran MTD, Wharton S, Yokote K, Zeuthen N, Kushner RF (2021) Impact of semaglutide on body composition in adults with overweight or obesity: exploratory analysis of the STEP 1 study
In addition, exendin-4 at 0.1100 nM concentrations for 2496 h increased GLP-1R activation, p53, p21, p38, cAMP, Bax/Bcl-2 ratio, and p38/MAPK activation
Many patients who struggle with obesity or overweight-related health concerns can benefit from GLP-1 even if they do not have diabetes
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