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Contrairement aux approches classiques de gestion du poids, le rtatrutide agit par un mcanisme sophistiqu ciblant plusieurs systmes physiologiques impliqus dans la rgulation de l'apptit et le mtabolisme du glucose

Guests: Diana Thiara, medical director, UCSF Weight Loss Management Program Whitney Casares, pediatrician

As the first-in-class glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist, Tirzepatide 5mg represents a major advancement in the treatment of type 2 diabetes mellitus in adults

Complementing these findings, preliminary data from human synovial fibroblasts show that GLP-1 stimulation reduces cytokine production and alters inflammatory gene expression, suggesting broader immunomodulatory effects across key synovial cell populations